If a fish on your line swims fast enough, will your rod burst into flames? A star drag reel gives Grant, Kari and Tory hope through some surprisingly hot results.

Usually you FILL potholes. But in order put his and Adam's makeshift flat-tire fixes to the test, Jamie Hyneman DIGS some. And builds speed bumps. And dumps water. And ...

Fact: Jamie Hyneman was riding a motorcycle before he had a driver's license. So, yes, Tablecloth Pull was AWESOME for him, especially when he exceeded 100 mph.

Jamie and Adam explain their confusion why, during Crash Landing, the plane simulator kept telling them, "Don't THINK." (It's because that's NOT what the plane was saying.)

The National Institute of Health's Building 10 was established by President Truman in 1951. He envisioned a place where doctors would have the time and resources to find cures for some of the world's biggest medical mysteries.

In this exclusive interview, Emmy-winning actor Jim Parsons ("The Big Bang Theory") explains why he wanted to provide the narration for Discovery series First In Human.

Job Syndrome is one of the rarest diseases in the world, for which there is no cure. For patients like Lucy Wiese, a first in human trial at Building 10 represents hope.

Dr. Terry Fry is a research oncologist at NIH's Building 10. He leads a first in human trial that looks to cure leukemia patients whose cancer has resisted all other treatments.

The doctors of Building 10 administer clinical trials decades in the making. But they claim it's the patients who are the real heroes in this scenario.

For patients like Lucy, a transplant could be both life-saving and life-threatening.

Restaurants dispose of 250 million gallons of used cooking oil each year. For entrepreneurs like Donnie Tipton, one man's trash is truly another man's treasure.

Business owner Jim Eberle explains the process of transforming used cooking oil into biodiesel, which can be used as a renewable replacement for diesel fuel.

An F5 tornado is heading straight for the hospital where Shay-la is having her labor induced. She's already had the epidural so there's no stopping the labor now.

A baby mountain goat gets separated from its mother and must battle the raging rapids to be reunited.

Olive Ridley sea turtle hatchlings run the gauntlet in Costa Rica. Only 5 out of 100 will make it through their first 8 hours out of the nest.

Watch a special sneak peek of the epic seven-part series North America. Discovery.com/NorthAmerica